Skip to toolbar

Tag: Alzheimer’s Disease

A short cut to the past: Cueing via concrete objects improves autobiographical memory retrieval in Alzheimer’s disease patients

Published in: Neuropsychologia, Volume 110, February 2018, 113-122 Abstract “Older adults diagnosed with Alzheimer’s disease (AD) have difficulties accessing autobiographical memories. However, this deficit tends to spare memories dated to earlier parts of their lives, and may partially reflect retrieval deficits rather than complete memory loss. Introducing a novel paradigm, the present study examines whether autobiographical memory recall can be improved in AD by manipulating the sensory richness, concreteness and cultural dating of the memory cues. Specifically, we examine whether concrete everyday objects historically dated to the participants’ youth (e.g., a skipping rope), relative to verbal cues (i.e., the verbal signifiers for the objects)… Read More

Evolution of autobiographical memory impairments in Alzheimer’s disease and frontotemporal dementia – A longitudinal neuroimaging study

Published in: Neuropsychologia, Volume 110, February 2018, 14-25 Abstract “Compromised autobiographical memory (ABM) retrieval is well established in dementia, attributable to degeneration of a core memory brain network. It remains unclear, however, how the progressive spread of atrophy with advancing disease severity impacts ABM retrieval across life epochs. To this end, we conducted a longitudinal study of recent and remote ABM in Alzheimer’s disease(AD, n =11), and a frontotemporal lobar degeneration group (FTD, n =13) comprising 7 behavioral variant FTD and 6 semantic dementia patients, in comparison with 23 healthy older Controls. Patients were re-assessed approximately one year following their initial visit and underwent repeat testing and brain imaging. Linear mixed… Read More