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Tag: Cognitive Function

Aging is associated with a prefrontal lateral-medial shift during picture-induced negative affect

Published in: Social Cognitive and Affective Neuroscience, Volume 13, Issue 2, 156-163 Abstract “The capacity to adaptively respond to negative emotion is in part dependent upon lateral areas of the prefrontal cortex (PFC). Lateral PFC areas are particularly susceptible to age-related atrophy, which affects executive function (EF). We used structural and functional magnetic resonance imaging (MRI) to test the hypothesis that older age is associated with greater medial PFC engagement during processing of negative information, and that this engagement is dependent upon the integrity of grey matter structure in lateral PFC as well as EF. Participants (n = 64, 38–79 years) viewed negative and… Read More