Learning & Memory – ESC Research

Elongator complex is required for long-term olfactory memory formation in Drosophila

Published in: Learning & Memory, Volume 25, Issue 4, 183-196 Abstract “The evolutionarily conserved Elongator Complex associates with RNA polymerase II for transcriptional elongation. Elp3 is the catalytic subunit, contains histone acetyltransferase activity, and is associated with neurodegeneration in humans. Elp1 is a scaffolding subunit and when mutated causes familial dysautonomia. Here, we show that elp3 and elp1 are required […]

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Mechanisms of critical period in the hippocampus underlie object location learning and memory in infant rats

Learning & Memory

Published in: Learning & Memory, Volume 25, Issue 4, 176-182 Abstract “Episodic memories in early childhood are rapidly forgotten, a phenomenon that is associated with “infantile amnesia,” the inability of adults to remember early-life experiences. We recently showed that early aversive contextual memory in infant rats, which is in fact rapidly forgotten, is actually not lost,

Mechanisms of critical period in the hippocampus underlie object location learning and memory in infant rats Read Post »

The effects of extinction-aroused attention on context conditioning

Learning & Memory

Published in: Learning & Memory, Volume 25, Issue 4, 165-175 Abstract “Two experiments assessed the effects of extinguishing a conditioned cue on subsequent context conditioning. Each experiment used a different video-game method where sensors predicted attacking spaceships and participants responded to the sensor in a way that prepared them for the upcoming attack. In Experiment 1

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Elucidating the mechanisms of fear extinction in developing animals: a special case of NMDA receptor-independent extinction in adolescent rats

Learning & Memory

Published in: Learning & Memory, Volume 25, Issue 4, 158-164 Abstract “NMDA receptors (NMDARs) are considered critical for the consolidation of extinction but recent work challenges this assumption. Namely, NMDARs are not required for extinction retention in infant rats as well as when extinction training occurs for a second time (i.e., reextinction) in adult rats. In

Elucidating the mechanisms of fear extinction in developing animals: a special case of NMDA receptor-independent extinction in adolescent rats Read Post »

α2-Adrenergic receptor activation promotes long-term potentiation at excitatory synapses in the mouse accessory olfactory bulb

Learning & Memory

Published in: Learning & Memory, Volume 25, Issue 4, 147-157 Abstract “The formation of mate recognition memory in mice is associated with neural changes at the reciprocal dendrodendritic synapses between glutamatergic mitral cell (MC) projection neurons and GABAergic granule cell (GC) interneurons in the accessory olfactory bulb (AOB). Although noradrenaline (NA) plays a critical role in

α2-Adrenergic receptor activation promotes long-term potentiation at excitatory synapses in the mouse accessory olfactory bulb Read Post »